Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A

• DOI: 10.1371/journal.pone.0004606
• Publication Date: 2009-02-25T23:54:22Z
• Authors: Fayçal Guedj; Catherine Sébrié; Isabelle Rivals; Aurelie Ledru; Evelyne Paly; Jean C. Bizot; Desmond Smith; Edward Rubin; Brigitte Gillet; Mariona Arbones; Jean M. Delabar
• Keywords: DYRK1A

Individuals with partial HSA21 trisomies and mice MMU16 containing an extra copy of the DYRK1A gene present various alterations in brain morphogenesis. They also learning impairments modeling those encountered Down syndrome. Previous MRI histological analyses a transgenic generated using human YAC construct that contains five genes including reveal is involved, during development, control volume cell density specific regions. Gene dosage correction induces rescue alterations. involved synaptic plasticity memory consolidation. Increased results morphogenesis defects, low BDNF levels mnemonic deficits these mice. Epigallocatechin gallate (EGCG) — member natural polyphenols family, found great amount green tea leaves safe inhibitor. We maintained overexpressing on two different polyphenol-based diets, from gestation to adulthood. The major features phenotype were rescued