Parkinson's Disease-Related Protein, α-Synuclein, in Malignant Melanoma

• DOI: 10.1371/journal.pone.0010481
• Publication Date: 2010-05-05T16:53:15Z
• Authors: Yasuhiro Matsuo; Tetsu Kamitani
• Keywords: Adult; Male; Skin Neoplasms; Retinoblastoma / metabolism / pathology; Science; Parkinson Disease / metabolism / pathology; 610; Skin Neoplasms / metabolism / pathology; Melanoma / metabolism / pathology; Brain Neoplasms / metabolism / pathology; Cell Line; 03 medical and health sciences; MART-1 Antigen; 0302 clinical medicine; Biological / metabolism; Antigens, Neoplasm; Cell Line, Tumor; Biomarkers, Tumor; Humans; Nevus / metabolism / pathology; Antigens; Tumor Markers; Melanoma; Nevus; Aged; Melanins; Tumor; alpha-Synuclein / metabolism; Brain Neoplasms; Pigmentation; Q; R; Retinoblastoma; Neoplasm / metabolism; Parkinson Disease; Middle Aged; Melanins / metabolism; Neoplasm Proteins; 3. Good health; alpha-Synuclein; Medicine; Female; Neoplasm Proteins / metabolism; Research Article

Melanoma is the major cause of skin cancer death worldwide. Parkinson's disease a neurodegenerative disorder that caused by mutation alpha-synuclein or other genes. Importantly, epidemiological studies have reported co-occurrence melanoma and disease, suggesting these two diseases could share common genetic components.Recently, we found human cell lines highly express alpha-synuclein, whereas protein undetectable in non-melanoma tested. To investigate expression tissues, immunostained sections melanoma, nevus, non-melanocytic cutaneous carcinoma, normal skin. alpha-Synuclein was positively detected 86% primary 85% metastatic sections, as well 89% nevus sections. However, carcinoma skin.The disease-related protein, expressed both malignant benign melanocytic lesions, such melanomas nevi. Although cannot be used to distinguish between it might useful biomarker for diagnosis melanoma.