Adherence to Antiretroviral Treatment and Correlation with Risk of Hospitalization among Commercially Insured HIV Patients in the United States

• DOI: 10.1371/journal.pone.0031591
• Publication Date: 2012-02-24T16:54:46Z
• Authors: Paul E. Sax; Juliana L. Meyers; Michael Mugavero; Keith L. Davis
• Keywords: Pill; Regimen

Purpose A lower daily pill burden may improve adherence to antiretroviral treatment (ART) and clinical outcomes in patients with human immunodeficiency virus (HIV). This study assessed differences using the number of pills taken per day, evaluated how correlated hospitalization. Methodology Commercially insured LifeLink database an HIV diagnosis (International Classification Diseases, 9th Revision, Clinical Modification code 042.xx) between 6/1/2006 12/31/2008 receipt a complete ART regimen were selected for inclusion. Patients grouped according their count remained on at least 60 days. Outcomes included rates Adherence was measured as proportion days start end which patient maintained supply all initiated components. Logistic regressions relationship adherence, hospitalization, controlling demographics, comorbidities, ART-naïve (vs. experienced) status. Results 7,073 met inclusion criteria, 33.4%, 5.8%, 60.8% received comprising one, two, or three more respectively. Regression analysis showed receiving single day significantly likely reach 95% threshold versus (odds ratio [OR] = 1.59; P<0.001). Regardless over 40% less have hospitalization if they adherent therapy (OR 0.57; 24% 0.76; P 0.003). Conclusions consisting associated better risk compared day.