Metabolic Disturbances Associated with Systemic Lupus Erythematosus

• DOI: 10.1371/journal.pone.0037210
• Publication Date: 2012-06-19T21:05:01Z
• Authors: Tianfu Wu; Chun Xie; Jie Han; Yujin Ye; Jim Weiel; Quan Li; Irene Blanco; Chul Ahn; Nancy Olsen; Chaim Putterman; Ramesh Saxena; Chandra Mohan
• Keywords: Metabolome; Fatty Acid Metabolism

The metabolic disturbances that underlie systemic lupus erythematosus are currently unknown. A metabolomic study was executed, comparing the sera of 20 SLE patients against healthy controls, using LC/MS and GC/MS platforms. Validation key differences performed an independent cohort 38 orthogonal assays. showed evidence profoundly dampened glycolysis, Krebs cycle, fatty acid β oxidation amino metabolism, alluding to reduced energy biogenesis from all sources. Whereas long-chain acids, including n3 n6 essential were significantly reduced, medium chain acids serum free elevated. metabolome exhibited profound lipid peroxidation, reflective oxidative damage. Deficiencies noted in cellular anti-oxidant, glutathione, methyl group donors, cysteine, methionine, choline, as well phosphocholines. best discriminators included elevated peroxidation products, MDA, gamma-glutamyl peptides, GGT, leukotriene B4 5-HETE. Importantly, similar elevations not observed another chronic inflammatory autoimmune disease, rheumatoid arthritis. To sum, comprehensive profiling reveals heightened stress, inflammation, generation, altered profiles a pro-thrombotic state. Resetting metabolome, either by targeting selected molecules or supplementing diet with vitamins donors offers novel opportunities for disease modulation this disabling ailment.