RhoT1 and Smad4 Are Correlated with Lymph Node Metastasis and Overall Survival in Pancreatic Cancer

• DOI: 10.1371/journal.pone.0042234
• Publication Date: 2012-07-31T21:12:41Z
• Authors: Hua Jiang; Chengzhi He; Shasha Geng; Haihui Sheng; Xiaoying Shen; Xiaoyan Zhang; Hang Li; Shizhang Zhu; Ximei Chen; Changqing Yang; HengJun Gao
• Keywords: Perineural invasion

Cancer cell invasion and metastasis are the most important adverse prognostic factors for pancreatic cancer. Identification of biomarkers associated with outcome cancer may provide new approaches targets anticancer therapy. The aim this study is to examine relationship between expression RhoT1, Smad4 p16 survival in patients analysis showed that high cytoplasmic levels tissues had significantly negative correlation lymph node (LNM) (P = 0.017, P 0.032, 0.042, respectively). However, no significant association was observed perineural (PNI) above three proteins (all P>0.05). Additionally, low RhoT1 were worse 0.034, 0.047, In conclusion, these results indicated low-expression LNM shorter survival. be considered as a potential novel marker predicting