The Effect of Exercise Training Modality on Serum Brain Derived Neurotrophic Factor Levels in Individuals with Type 2 Diabetes

• DOI: 10.1371/journal.pone.0042785
• Publication Date: 2012-08-06T21:14:32Z
• Authors: Damon L. Swift; Neil M. Johannsen; Valerie H. Myers; Conrad P. Earnest; Jasper A. J. Smits; Steven N. Blair; Timothy S. Church
• Keywords: Aerobic Exercise

Brain derived neurotrophic factor (BDNF) has been implicated in memory, learning, and neurodegenerative diseases. However, the relationship of BDNF with cardiometabolic risk factors is unclear, effect exercise training on not previously explored individuals type 2 diabetes.Men women (N = 150) diabetes were randomized to an aerobic (aerobic), resistance (resistance), or a combination both (combination) for 9 months. Serum levels evaluated at baseline follow-up from archived blood samples.Baseline serum was associated fitness, body composition, anthropometry, glucose control, strength measures (all, p>0.05). Similarly, no significant change observed following (-1649.4 pg/ml, CI: -4768.9 1470.2), (-2351.2 CI:-5290.7 588.3), groups (-827.4 -3533.3 1878.5) compared control group (-2320.0 -5750.8 1110.8). reductions waist circumference directly changes (r 0.25, p 0.005).Serum baseline. Likewise, altered by months aerobic, resistance, training. decreased levels. Future studies should investigate relevance cognitive function specifically type-2 diabetes.