Elevated Plasma Angiopoietin-2 Levels and Primary Graft Dysfunction after Lung Transplantation

• DOI: 10.1371/journal.pone.0051932
• Publication Date: 2012-12-20T01:19:32Z
• Authors: Joshua M. Diamond; Mary K. Porteous; Edward Cantu; Nuala J. Meyer; Rupal J. Shah; David J. Lederer; Steven M. Kawut; James Lee; Scarlett L. Bellamy; Scott M. Palmer; Vibha N. Lama; Sangeeta M. Bhorade; Maria Crespo; Ejigayehu Demissie; Keith Wille; Jonathan Orens; Pali D. Shah; Ann Weinacker; David Weill; Selim Arcasoy; David S. Wilkes; Lorraine B. Ware; Jason D. Christie
• Keywords: Angiopoietin 2; Angiopoietin; Angiopoietin receptor

Introduction Primary graft dysfunction (PGD) is a significant contributor to early morbidity and mortality after lung transplantation. Increased vascular permeability in the allograft has been identified as possible mechanism leading PGD. Angiopoietin-2 serves partial antagonist Tie-2 receptor induces increased endothelial permeability. We hypothesized that elevated Ang2 levels would be associated with development of Methods performed case-control study, nested within multi-center Lung Transplant Outcomes Group cohort. Plasma angiopoietin-2 were measured pre-transplant 6 24 hours post-reperfusion. The primary outcome was grade 3 PGD first 72 hours. association plasma evaluated using generalized estimating equations (GEE). Results There 40 subjects 79 non-PGD included for analysis. Twenty-four (40%) 47 (59%) received transplant diagnosis idiopathic pulmonary fibrosis (IPF). Among all subjects, GEE modeling change level over time cases compared controls (p = 0.03). between perioperative period most patients pre-operative IPF 0.02); there no statistically correlation subset transplanted chronic obstructive disease (COPD) 0.9). Conclusions significantly Further studies examining regulation cell pathogenesis are indicated.