Normal Muscle Oxygen Consumption and Fatigability in Sickle Cell Patients Despite Reduced Microvascular Oxygenation and Hemorheological Abnormalities

• DOI: 10.1371/journal.pone.0052471
• Publication Date: 2012-12-20T22:37:31Z
• Authors: Xavier Waltz; Aurélien Pichon; Nathalie Lemonne; Danièle Mougenel; Marie-Laure Lalan...; Yann Lamarre; Vanessa Tarer; Benoit Tressières; Maryse Etienne-Julan; Marie-Dominique H...; Olivier Hue; Philippe Connes
• Keywords: Vasomotion

Although it has been hypothesized that muscle metabolism and fatigability could be impaired in sickle cell patients, no study addressed this issue.We compared function (muscle microvascular oxygenation, blood flow, oxygen consumption oxygenation variability, which reflects vasomotion activity, maximal force local fatigability) the hemorheological profile at rest between 16 healthy subjects (AA), 20 cell-hemoglobin C disease (SC) patients anemia (SS) patients.Muscle was reduced SS to SC AA groups reduction not related hemorhelogical abnormalities. No difference observed three for activity. Muscle flow higher group, tended group. Multivariate analysis revealed independently associated with two (SC SS). Finally, despite their similar of subjects.Sickle have normal resting alterations and, only, increased flow. Two alternative mechanisms can proposed patients: 1) is a way compensate lower maintain values or 2) coupled indicate there slight hypoxia within sufficient limit mitochondrial respiration but increases