Decreased Plasma IL-35 Levels Are Related to the Left Ventricular Ejection Fraction in Coronary Artery Diseases

• DOI: 10.1371/journal.pone.0052490
• Publication Date: 2012-12-22T01:42:39Z
• Authors: Yingzhong Lin; Ying Huang; Zhengde Lu; Cheng Luo; Ying shi; Qiutang Zeng; Yifeng Cao; Lin Liu; Xiaoyan Wang; Qingwei Ji
• Keywords: Unstable angina

Background Accumulating evidence shows that the novel anti-inflammatory cytokine IL-35 can efficiently suppress effector T cell activity and alter progression of inflammatory autoimmune diseases. The two subunits IL-35, EBI3 p35, are strongly expressed in human advanced plaque, suggesting a potential role atherosclerosis coronary artery disease (CAD). However, plasma levels patients with CAD have yet to be investigated. Methods Plasma IL-10, TGF-β1, IL-12 IL-27 were measured using an ELISA 43 stable angina pectoris (SAP) patients, 62 unstable (UAP) 56 acute myocardial infarction (AMI) 47 chest pain syndrome as control group. Results results showed significantly decreased SAP group (90.74±34.22 pg/ml), UAP (72.20±26.63 AMI (50.21±24.69 pg/ml) compared (115.06±32.27 pg/ml). Similar also demonstrated IL-10 TGF-β1. increased (349.72±85.22 pg/ml, 101.75±51.42 respectively) (318.05±86.82 148.88±68.45 (138.68±34.37 63.60±22.75 (153.84±53.86 70.84±38.77 respectively). Furthermore, lower moderately positively correlated left ventricular ejection fraction (LVEF) (R = 0.416, P<0.01), whereas higher weakly negatively LVEF patients(R −0.205, P<0.01). Conclusions present study show circulating is potentially biomarker for disease. Regulating expression provides new possible target treatment CAD.