Development and Validation of a Vitamin D Status Prediction Model in Danish Pregnant Women: A Study of the Danish National Birth Cohort

• DOI: 10.1371/journal.pone.0053059
• Publication Date: 2013-01-10T00:15:32Z
• Authors: Camilla Bjørn Jensen; Andrew L. Thorne-...; Linda Vadgård Hansen; Marin Strøm; Nina Odgaard Nielsen; Arieh Cohen; Sjurdur Frodi Olsen
• Keywords: Danish; Decile

Vitamin D has been hypothesized to reduce risk of pregnancy complications such as preeclampsia, gestational diabetes mellitus, and preterm delivery. However, many these outcomes are rare require a large sample size study, representing challenge for cohorts with limited number preserved samples. The aims this study were (1) identify predictors serum 25-hydroxy-vitamin (25(OH)D) among pregnant women in subsample (N = 1494) the Danish National Birth Cohort (DNBC) (2) develop validate score predicting 25(OH)D-status order explore associations between vitamin maternal offspring health DNBC. In our sample, 42.3% population had deficient levels (<50 nmol/L 25(OH)D) average 56.7(s.d. 24.6) nmol/L. A prediction model consisting intake from diet supplements, outdoor physical activity, tanning bed use, smoking, month blood draw explained 40.1% variance 25(OH)D mean measured 25(OH)D-level increased linearly by decile predicted 25(OH)D-score. total 32.2% placed same quintile both 25(OH)D-values 69.9% or adjacent methods. Cohen's weighted kappa coefficient (Κ 0.3) reflected fair agreement 25(OH)D-levels These results comparable other settings which scores have shown similar disease 25(OH)D-levels. Our findings suggest that 25(OH)D-scores may be useful alternative examining DNBC cohort, but cannot substitute estimates prevalence.