Disease Activity in Inflammatory Bowel Disease Is Associated with Increased Risk of Myocardial Infarction, Stroke and Cardiovascular Death – A Danish Nationwide Cohort Study

• DOI: 10.1371/journal.pone.0056944
• Publication Date: 2013-02-15T23:08:43Z
• Authors: Søren Lund Kriste...; Ole Ahlehoff; Jesper Lindhardsen; Rune Erichsen; Gunnar Vagn Jensen; Christian Torp-Pe...; Ole Haagen Nielsen; Gunnar Hilmar Gis...; Peter Riis Hansen
• Keywords: Stroke; Rate ratio

Purpose Chronic inflammatory diseases have been linked to increased risk of atherothrombotic events, but the associated with bowel disease (IBD) is unclear. We therefore examined myocardial infarction (MI), stroke, and cardiovascular death in patients IBD. Methods In a nationwide Danish population-based setting, cohort incident IBD between 1996 2009 were identified national registers. Hospitalizations as primary diagnosis, initiation biological treatment dispensed prescriptions corticosteroids all used surrogate markers for activity, flares classified first 120 days after diagnosis IBD, new corticosteroid prescription, or hospitalization, respectively. Continued hospitalizations defined persistent periods free such events remissions. Poisson regression was examine MI, using matched comparison reference Results 20,795 mean age 40.3 years that according sex 199,978 controls. During study period, there 365 454 778 death. Patients had an overall MI (rate ratio [RR] 1.17 [95% confidence interval 1.05–1.31]), stroke (RR 1.15 [1.04–1.27], 1.35 [1.25–1.45]). activity RRs 1.49 (1.16–1.93) 2.05 (1.58–2.65), 1.53 (1.22–1.92) 1.55 (1.18–2.04) 2.32 (2.01–2.68) 2.50 (2.14–2.92). remission periods, similar Conclusion Inflammatory during active disease.