Mitochondrial Network Genes in the Skeletal Muscle of Amyotrophic Lateral Sclerosis Patients

Male 0301 basic medicine amyotrophic lateral sclerosis Principal Component Analysis Science Q Amyotrophic Lateral Sclerosis R In Vitro Techniques Middle Aged Mitochondria 03 medical and health sciences Genes, Mitochondrial Medicine Humans Female Gene Regulatory Networks Muscle, Skeletal Transcriptome Research Article Aged
DOI: 10.1371/journal.pone.0057739 Publication Date: 2013-03-01T13:38:29Z
ABSTRACT
Recent evidence suggested that muscle degeneration might lead and/or contribute to neurodegeneration, thus it possibly play a key role in the etiopathogenesis and progression of amyotrophic lateral sclerosis (ALS). To test this hypothesis, study attempted categorize functionally relevant genes within genome-wide expression profile human ALS skeletal muscle, using microarray technology gene regulatory network analysis. The correlation structures significantly change between patients controls, indicating an increased inter-gene connection compared controls. observed group seems reflect perturbation homeostasis metabolic balance occurring affected individuals. In particular, muscles includes (PRKR1A, FOXO1, TRIM32, ACTN3, among others), whose functions connect sarcomere integrity mitochondrial oxidative metabolism. Overall, analytical approach used offer possibility observe higher levels (i.e. common trends) genes, function be aberrantly activated during atrophy.
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