Mitochondrial Network Genes in the Skeletal Muscle of Amyotrophic Lateral Sclerosis Patients
Male
0301 basic medicine
amyotrophic lateral sclerosis
Principal Component Analysis
Science
Q
Amyotrophic Lateral Sclerosis
R
In Vitro Techniques
Middle Aged
Mitochondria
03 medical and health sciences
Genes, Mitochondrial
Medicine
Humans
Female
Gene Regulatory Networks
Muscle, Skeletal
Transcriptome
Research Article
Aged
DOI:
10.1371/journal.pone.0057739
Publication Date:
2013-03-01T13:38:29Z
AUTHORS (10)
ABSTRACT
Recent evidence suggested that muscle degeneration might lead and/or contribute to neurodegeneration, thus it possibly play a key role in the etiopathogenesis and progression of amyotrophic lateral sclerosis (ALS). To test this hypothesis, study attempted categorize functionally relevant genes within genome-wide expression profile human ALS skeletal muscle, using microarray technology gene regulatory network analysis. The correlation structures significantly change between patients controls, indicating an increased inter-gene connection compared controls. observed group seems reflect perturbation homeostasis metabolic balance occurring affected individuals. In particular, muscles includes (PRKR1A, FOXO1, TRIM32, ACTN3, among others), whose functions connect sarcomere integrity mitochondrial oxidative metabolism. Overall, analytical approach used offer possibility observe higher levels (i.e. common trends) genes, function be aberrantly activated during atrophy.
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