Variable Stromal Periductular Expression of CD34 and Smooth Muscle Actin (SMA) in Intraductal Carcinoma of the Breast

• DOI: 10.1371/journal.pone.0057773
• Publication Date: 2013-03-02T08:13:19Z
• Authors: Xavier Catteau; Philippe Simon; Michel Vanhaeverbeek; Jean-Christophe Noël
• Keywords: Fibrocyte; Breast carcinoma

In breast carcinoma, the stromal loss of CD34 expression and acquisition SMA myofibroblastic features may constitute a prerequisite for tumor invasiveness. However, this hypothesis remains controversial, with some authors describing fibrocytes in absence myofibroblastic-like cells stroma invasive carcinoma. Others have also described disappearance from situ To clarify issue, we compared distribution reactive myofibroblasts between areas tumor-free mammary tissue, ductal carcinoma (DCIS) (IDC). addition to 28 IDC, 300 normal duct-lobular units 600 ducts DCIS (158 low-grade, 266 intermediate, 176 high-grade) were scored. The relationships staining patterns different histological (grade presence or necrosis) compared. Loss more frequent high-grade lesions than intermediate low-grade (p<0.001). When necrosis was found association grade 2 3 DCIS, decrease higher without that independently (p<0.05). Necrosis did not appear play significant role (p = 0.35). all cases, carcinomas showed complete fibrocytes. Future research on both mechanisms changes are essential future potentially lead new treatment approaches.