Comparisons of Primary HIV-1 Drug Resistance between Recent and Chronic HIV-1 Infection within a Sub-Regional Cohort of Asian Patients

• DOI: 10.1371/journal.pone.0062057
• Publication Date: 2013-06-27T21:15:05Z
• Authors: Sasisopin Kiertib...; Romanee Chaiwarith; Sunee Sirivichayakul; Rossana Ditangco; Awachana Jiamsakul; Patrick C. K. Li; Pacharee Kantipong; Christopher Lee; Winai Ratanasuwan; Adeeba Kamarulzaman; Annette H. Sohn; Somnuek Sungkanup...
• Keywords: HIV drug resistance

The emergence and transmission of HIV-1 drug resistance (HIVDR) has raised concerns after rapid global antiretroviral therapy (ART) scale-up. There are limited data on the epidemiology primary HIVDR in resource-limited settings Asia. We aimed to determine prevalence compare distribution a cohort ART-naïve Asian patients with recent chronic infection.Multicenter prospective study was conducted between 2007 2010. Resistance-associated mutations (RAMs) were assessed using World Health Organization 2009 list for surveillance HIVDR.A total 458 1,340 infection included analysis. overall 4.6%. Recently infected had higher (6.1% vs. 4.0%, p = 0.065) frequencies RAMs protease inhibitors (PIs; 3.9% 1.0%, p<0.001). Among those infection, most common nucleoside reverse transcriptase (NRTIs) M184I/V T215D/E/F/I/S/Y (1.1%), non-NRTIs Y181C (1.3%), PIs M46I (1.5%). Of (0.8%; NRTI), (0.5%; non-NRTI), (0.4%; PI) RAMs. K70R (p 0.016) 0.026) found more frequently among recently patients. In multivariate logistic regression analysis heterosexual contact as risk factor less likely be associated compared other categories (odds ratio 0.34, 95% confidence interval 0.20-0.59, p<0.001).The than our cohort, but borderline statistical significance. Chronically non-heterosexual risks HIV have HIVDR.