Internalization of Met Requires the Co-Receptor CD44v6 and Its Link to ERM Proteins

• DOI: 10.1371/journal.pone.0062357
• Publication Date: 2013-04-23T18:14:44Z
• Authors: Susanne Hasenauer; Dieter Malinger; David Koschut; Giuseppina Pace; Alexandra Matzke; Anja von Au; Véronique Orian-R...
• Keywords: Internalization

Receptor Tyrosine Kinases (RTKs) are involved in many cellular processes and play a major role the control of cell fate. For these reasons, RTK activation is maintained under tight control. Met an essential that induces proliferation, differentiation, migration, survival branching morphogenesis. Deregulation by overexpression, amplification or lack effective degradation leads to cancer metastasis. We have shown relies on CD44v6 for its signaling several lines also primary cells. In this paper, we show internalization dependent binding Ezrin cytoplasmic domain. Both co-internalized upon Hepatocyte Growth Factor induction suggesting Met-induced from endosomes collaboration with link cytoskeleton provided ERM proteins.