Novel Insights into the Bovine Polled Phenotype and Horn Ontogenesis in Bovidae

• DOI: 10.1371/journal.pone.0063512
• Publication Date: 2013-05-22T22:29:44Z
• Authors: Aurélie Allais-Bo...; Cécile Grohs; Ivica Medugorac; Stefan Krebs; Anis Djari; Alexander Graf; Sébastien Fritz; Doris Seichter; Aurélia Baur; Ingolf Russ; Stéphan Bouet; Sophie Rothammer; Per Wahlberg; Diane Esquerré; Chris Hoze; Mekki Boussaha; Bernard Weiss; Dominique Thépot; Marie-Noëlle Foui...; Marie-Noëlle Ross...; Este van Marle-Kö...; Gunnfríður Elín H...; Sarah Barbey; Dominique Dozias; Emilie Cobo; Patrick Reversé; Olivier Catros; Jean-Luc Marchand; Pascal Soulas; Pierre Roy; Brigitte Marquant...; Daniel Le Bourhis; Laetitia Clément; Laura Salas-Cortes; Eric Venot; Maëlle Pannetier; Florence Phocas; Christophe Klopp; Dominique Rocha; Michel Fouchet; Laurent Journaux; Carine Bernard-Capel; Claire Ponsart; André Eggen; Helmut Blum; Yves Gallard; Didier Boichard; Eric Pailhoux; Aurélien Capitan
• Keywords: Horn ontogenesis; [SDV.SA]Life Sciences [q-bio]/Agricultural sciences; 0301 basic medicine; 570; corne; Genotype; Science; Celtic allele; Receptors, G-Protein-Coupled; bovidae; 03 medical and health sciences; Basic Helix-Loop-Helix Transcription Factors; Animals; Alleles; Horns; Sheep; Goats; Q; R; Chromosome Mapping; Gene Expression Regulation, Developmental; Genetic Variation; Forkhead Transcription Factors; phénotype; ontogénèse; Phenotype; Mutation; Bovidae; Medicine; Cattle; Bovine polledness; Research Article

Despite massive research efforts, the molecular etiology of bovine polledness and developmental pathways involved in horn ontogenesis are still poorly understood. In a recent article, we provided evidence for existence at least two different alleles Polled locus identified candidate mutations each them. None these was located known coding or regulatory regions, thus adding to complexity understanding basis polledness. We confirm previous results here exhaustively identify causative mutation Celtic allele (PC) four Friesian (PF). describe previously unreported eyelash-and-eyelid phenotype associated with regular polledness, present unique histological gene expression data on bud differentiation fetuses affected by three defect syndromes, as well wild-type controls. propose ectopic lincRNA PC/p buds probable cause agenesis. addition, provide an involvement OLIG2, FOXL2 RXFP2 differentiation, draw first link between bovine, ovine caprine loci. Our represent important step genetic key process Bovidae.