Epicardial Adipose Tissue in Patients with Chronic Obstructive Pulmonary Disease

• DOI: 10.1371/journal.pone.0065593
• Publication Date: 2013-06-06T17:08:49Z
• Authors: Jorge Zagaceta; Javier J. Zulueta; Gorka Bastarrika; Inmaculada Colina; Ana B. Alcaide; Arantza Campo; Bartolome R. Celli; Juan P. de Torres
• Keywords: BODE index; Microalbuminuria; Coronary Calcium Score; Epicardial adipose tissue

Epicardial Adipose Tissue (EAT) volume as determined by chest computed tomography (CT) is an independent marker of cardiovascular events in the general population. COPD patients have increased risk disease, however nothing known about EAT this population.To assess and explore its association with clinical physiological variables disease severity.We measured using low-dose CT 171 stable 70 controls matched age, smoking history BMI. We blood pressure, cholesterol, glucose HbA1c levels, microalbuminuria, lung function, BODE index, co-morbidity index coronary artery calcium score (CAC). were compared between groups. Uni multivariate analyses explored relationship related variables.COPD had a higher [143.7 (P25-75, 108.3-196.6) vs 129.1 91.3-170.8) cm(3), p = 0.02)] was significantly associated CAC (r 0.38, p<0.001) CRP 0.32, but not microalbuminuria 0.12, 0.13). In patients, with: pack-years, BMI, gender, FEV1%, 6 MWD, MMRC HTN. Multivariate analysis showed that only pack-years (B 0.6, 95% CI: 0.5-1.3), BMI 7.8, 5.7-9.9) MWD -0.2, -0.3--0.1), predicted volume.EAT independently history, exercise capacity, all modifiable factors future events. could be non-invasive at high for