High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers

• DOI: 10.1371/journal.pone.0074855
• Publication Date: 2013-09-23T21:56:44Z
• Authors: Olivier Lambotte; Justin Pollara; Faroudy Boufassa; Christiane Moog; Alain Venet; Barton F. Haynes; Jean-François Del...; Asier Saez-Cirion; Guido Ferrari
• Keywords: Adult; Male; [SDV.IMM] Life Sciences [q-bio]/Immunology; Science; HIV Infections; CD8-Positive T-Lymphocytes; Antibodies, Viral; Antibodies; HIV Long-Term Survivors; 03 medical and health sciences; 0302 clinical medicine; Humans; Viral; Viremia; Q; R; Antibody-Dependent Cell Cytotoxicity; Middle Aged; 3. Good health; HLA-B Antigens; Multivariate Analysis; HIV-1; Linear Models; [SDV.IMM]Life Sciences [q-bio]/Immunology; Medicine; RNA; RNA, Viral; Female; Research Article

The role of Antibody-dependent cellular cytotoxicity (ADCC) responses in HIV-1 controllers is still unclear due to the heterogeneity of these patients. We analyzed 67 HIV-1 controllers and found significantly higher levels of ADCC antibodies in controllers versus viremic subjects (p = 0.017). Moreover, multivariate analysis revealed significantly higher ADCC titers in HLA B57- controllers compared to HLA-B57+ ones (p = 0.0086). These data suggest a role for ADCC in immune control of HIV, especially in HLA B57 negative controllers.