Identify Changes of Brain Regional Homogeneity in Bipolar Disorder and Unipolar Depression Using Resting-State fMRI

• DOI: 10.1371/journal.pone.0079999
• Publication Date: 2013-12-04T23:59:38Z
• Authors: Min-Jie Liang; Quan Zhou; Kan-Rong Yang; Xiao-Ling Yang; Jin Fang; Wen-Li Chen; Zheng Huang
• Keywords: Occipital lobe; Parietal lobe; Limbic lobe

Background To identify changes in brain activation patterns bipolar disorder (BD) and unipolar depression (UD) patients. Methodology/Principal Findings Resting-state fMRI scans of 16 healthy controls, 17 BD UD patients were obtained. T-test normalized regional homogeneity (ReHo) was performed a voxel-by-voxel manner. A combined threshold á = 0.05, minimum cluster volume V 10503 mm3 (389 voxels) used to determine ReHo differences between groups. In group, revealed increases the left middle occipital lobe, right inferior parietal lobule, precuneus convolution; decreases parahippocampalgyrus, precentralgyrus, postcentralgyrus, precentralgyrus cingulated. insular cortex, frontal gyrus, precuneus, parietal, superior gyrus thalamus; anterior lobe cerebellum, pons, cingulate. There some overlaps profiles groups, but marked difference seen thalamus BD. Conclusions/Significance The resting-state mapping are promising tool assist detection functional deficits distinguish clinical pathophysiological signs UD.