Relationships between HDL-C, hs-CRP, with Central Arterial Stiffness in Apparently Healthy People Undergoing a General Health Examination

• DOI: 10.1371/journal.pone.0081778
• Publication Date: 2013-12-03T21:26:30Z
• Authors: Xi Wang; YingZhen Du; Li Fan; Ping Ye; Ying Yuan; XueChun Lu; Fan Wang; Qiang Zeng
• Keywords: Quartile

BackgroundSome cardiovascular risk factors have been confirmed to be positively correlated with arterial stiffness. However, it is unclear whether HDL-C, a well-established anti-risk factor, has an independent association The aim of this study was evaluate the relationship between HDL-C levels and stiffness possible role high-sensitivity C-reactive protein (hs-CRP) in potential correlation apparently healthy adults undergoing general health examination China. Materials MethodsThis cross-sectional survey. In total, 15,302 participants (age range, 18–82 years; mean, 43.88±8.44 years) were recruited during routine status examinations. A questionnaire used we measured body mass index, systolic diastolic blood pressure, fasting glucose, serum lipid, uric acid, hs-CRP, creatinine each participant. Central assessed by carotid–femoral pulse wave velocity (cf-PWV). ResultsHDL-C decreased as cf-PWV increased. Pearson's analysis revealed that associated (r=−0.18, P<0.001). hs-CRP (r=0.13). After adjustment for all confounders, inversely independently quartiles cf-PWV. Furthermore, different coefficients (r) gradually increasing (quartiles 1–4). ConclusionsHDL-C central anti-inflammatory activity may mediate its Further, long-term follow-up studies are needed high protective against artery stiffening through HDL-C.