Modeling the Dynamics of a Non-Limited and a Self-Limited Gene Drive System in Structured Aedes aegypti Populations

• DOI: 10.1371/journal.pone.0083354
• Publication Date: 2013-12-10T21:44:04Z
• Authors: Mathieu Legros; Chonggang Xu; Amy Morrison; Thomas W. Scott; Alun L. Lloyd; Fred Gould
• Keywords: Gene drive

Recently there have been significant advances in research on genetic strategies to control populations of disease-vectoring insects. Some these use the gene drive properties selfish elements spread physically linked anti-pathogen genes into local vector populations. Because potential through populations, approaches based must be carefully evaluated ensure a balance between desirable refractoriness-conferring cargo and avoidance potentially unwanted outcomes such as non-target There is also need develop better estimates economics releases. We present here an evaluation two using biologically realistic mathematical model that simulates resident Aedes aegypti mosquito population Iquitos, Peru. One strategy uses element Medea, non-limited could permanently over large geographic area; other relies Killer-Rescue constructs, has predicted limited spatial temporal spread. simulate various operational for deploying strategies, quantify optimal number released transgenic mosquitoes needed achieve definitive Medea-linked and/or high frequencies Killer-Rescue-associated elements. show both most efficient approach achieving within three years generally release adults sexes multiple releases time. Even though females should not transmit disease, public concern releases, making less male-only more practical. This study provides guidelines replacement well illustrates detailed models assist safe implementation novel strategies.