Plant-Associated Symbiotic Burkholderia Species Lack Hallmark Strategies Required in Mammalian Pathogenesis

• DOI: 10.1371/journal.pone.0083779
• Publication Date: 2014-01-08T21:49:18Z
• Authors: Annette A. Angus; Christina M. Agap...; Stephanie Fong; Shailaja Yerrapra...; Paulina Estrada-d...; Paul Yang; Nannie Song; Stephanie Kano; Jésus Caballero-M...; Sergio M. de Faria; Felix D. Dakora; George Weinstock; Ann M. Hirsch
• Keywords: Burkholderia pseudomallei; Lineage (genetic); Burkholderia cepacia complex

Burkholderia is a diverse and dynamic genus, containing pathogenic species as well that form complex interactions with plants. Pathogenic strains, such B. pseudomallei mallei, can cause serious disease in mammals, while other strains are opportunistic pathogens, infecting humans or animals compromised immune system. Although some of the pathogens known to promote plant growth even fix nitrogen, risk infection infants, elderly, people who immunocompromised has not only resulted restriction on their use, but also limited application non-pathogenic, symbiotic species, several which nodulate legume roots have positive effects growth. However, recent phylogenetic analyses demonstrated separate into distinct lineages, suggesting possibility for safe use certain agricultural contexts. A number environmental degrade xenobiotics included lineage. Many these potential enhance agriculture areas where fertilizers readily available may serve future inocula crops growing soils impacted by climate change. Here we address using bioinformatics functional tests. series experiments Caenorhabditis elegans HeLa cells, genomic characterization loci, show tuberum extremely low.