MiR-26a Promotes Ovarian Cancer Proliferation and Tumorigenesis

• DOI: 10.1371/journal.pone.0086871
• Publication Date: 2014-01-22T22:47:55Z
• Authors: Wenjing Shen; Min Song; Jie Liu; Guangrong Qiu; Tianren Li; Yanjie Hu; Hongbo Liu
• Keywords: Ectopic expression

MicroRNAs (miRNAs) important for posttranscriptional gene expression are involved in the initiation and progression of human cancer. In this study, we reported that miR-26a was over-expressed EOC specimens level extracellular plasma can distinguish patients from healthy controls EOC. Ectopic ovarian cancer (OC) cells increased cell proliferation clonal formation. This growth promoting effect OC mediated by inhibition posttranscription ER-α. Furthermore, suppressed tumor formation generated injecting nude mice. Our results suggest aberrantly expressed may contribute to development.