Nasopharyngeal Carriage of Streptococcus pneumonia in Pneumonia-Prone Age Groups in Semarang, Java Island, Indonesia

• DOI: 10.1371/journal.pone.0087431
• Publication Date: 2014-01-31T22:52:13Z
• Authors: Helmia Farida; Juliëtte A. Severin; M. Hussein Gasem; Monique Keuter; Hendro Wahyono; Peterhans van den...; Peter W. M. Hermans; Henri A. Verbrugh
• Keywords: Carriage; Pneumococcal infections

Introduction Streptococcus pneumoniae is a worldwide occurring pathogen Nasopharyngeal carriage of precedes pneumonia and other pneumococcal diseases in the community. Little known about S. Indonesia, complicating strategies to control diseases. We investigated nasopharyngeal Semarang, Indonesia. Methods A population-based survey was performed swabs questionnaires were taken from 496 healthy young (6–60 month-old) children 45–70 year-old adults. Results Forty-three percent aged 6–60 months 11% adults 45–75 years carried pneumoniae. Determinants being child (OR 7.7; 95% CI = 4.5–13.0), passive smoking 2.1; 1.3–3.4), contact with toddler(s) at home 3.0; 1.9–4.7). The most frequent serotypes found 6A/B 15B/C. current commercially available vaccines cover <50% children. Twenty-four strains penicillin non-susceptible, 45% resistant cotrimoxazol. Conclusions limited coverage against this population, high proportion non-susceptibility cotrimoxazol suggest need for region-specific information