Co-Delivery of Doxorubicin and SATB1 shRNA by Thermosensitive Magnetic Cationic Liposomes for Gastric Cancer Therapy

• DOI: 10.1371/journal.pone.0092924
• Publication Date: 2014-03-27T21:02:02Z
• Authors: Zhao Peng; Chenxiao Wang; Erhu Fang; Xiaoming Lu; Guobin Wang; Qiang Tong
• Keywords: Male; Science; Transfection; 03 medical and health sciences; Drug Delivery Systems; Stomach Neoplasms; Cell Line, Tumor; Animals; Humans; Gene Silencing; Particle Size; RNA, Small Interfering; 0303 health sciences; Q; R; Gene Transfer Techniques; Matrix Attachment Region Binding Proteins; Xenograft Model Antitumor Assays; Tumor Burden; 3. Good health; Disease Models, Animal; Drug Liberation; Doxorubicin; Liposomes; Medicine; Thermodynamics; Research Article

In previous a study, we had developed novel thermosensitive magnetic delivery system based on liposomes. This study aimed to evaluate the efficiency of this for co-delivery both drugs and genes same cell its anti-tumor effects gastric cancer. Doxorubicin (DOX) SATB1 shRNA vector were loaded into system, in vitro DOX release activity, targeted gene silencing efficiency, cellular uptake, cytotoxicity, as well vivo activity determined. The results showed that desirable efficacy, silencing. Moreover, exhibited enhanced inhibit cancer growth vivo, compared single delivery. conclusion, drug has promising application combined chemotherapy therapy