Prevalence and Trend of Major Transfusion-Transmissible Infections among Blood Donors in Western China, 2005 through 2010

• DOI: 10.1371/journal.pone.0094528
• Publication Date: 2014-04-08T21:50:42Z
• Authors: Yan Song; Ying Bian; Max Petzold; Carolina Oi Lam Ung
• Keywords: Adult; Male; China; Adolescent; Science; Q; R; Transfusion Reaction; Blood Donors; Middle Aged; Communicable Diseases; 3. Good health; Young Adult; 03 medical and health sciences; Cross-Sectional Studies; 0302 clinical medicine; Risk Factors; Odds Ratio; Prevalence; Medicine; Humans; Female; Child; Research Article

Background The prevalence of transfusion-transmissible infections (TTIs) in blood donations is important for evaluating safety and potential risks to the population. This study investigated TTIs among donors Western China suggested measures policy-makers. Methods screening results 66,311 between 2005 2010 from a central center were analyzed. hepatitis B virus (HBV), C (HCV), human immunodeficiency (HIV), syphilis expressed percentages entire group as well groups by demographic characteristics donation frequency, with differences analyzed using Fisher's exact or Chi-square test. Logistic regression was performed identify influencing factors detected results. Results 1,769 (2.67%, 95% CI 2.55–2.79%) donated had serological evidence infection at least one pathogen 44 (0.07%, 0.05–0.09%) showed multiple infections. seroprevalence HBV, HCV, HIV, 0.87% (95% 0.80–0.94%), 0.86% 0.79–0.93%), 0.31% 0.26–0.35%), 0.70% 0.64–0.76%) respectively. Trend analysis significant increase 2.44% 3.71% (χ2 = 100.72, p 0.00) over this 6-year period. positive rates varied along lines. top three risk test-positive identified age, education level frequency. older age lower educated linked higher TTIs. A decreasing associated an increasing frequency 562.78, 0.00). Conclusions Hepatitis found most, often conjunction syphilis. These primary threats safety. high positivity rate call further actions.