Relationship between Interleukin-6 Gene Polymorphism and Hippocampal Volume in Antipsychotic-Naïve Schizophrenia: Evidence for Differential Susceptibility?

• DOI: 10.1371/journal.pone.0096021
• Publication Date: 2014-05-02T20:24:46Z
• Authors: Sunil Vasu Kalmady; Ganesan Venkatasu...; Venkataram Shivak...; S. Gautham; Aditi Subramaniam; Dania Alphonse Jose; Arindam Maitra; Vasanthapuram Ravi; Bangalore N. Gang...
• Keywords: Genetic predisposition

Background Various lines of evidence including epidemiological, genetic and foetal pathogenetic models suggest a compelling role for Interleukin-6 (IL-6) in the pathogenesis schizophrenia. IL-6 mediated inflammatory response triggered by maternal infection or stress induces disruption prenatal hippocampal development which might contribute towards psychopathology during adulthood. There is substantial lack knowledge on how predisposition to elevated expression effects structure schizophrenia patients. In this first-time study, we evaluated relationship between functional polymorphism rs1800795 gray matter volume antipsychotic-naïve patients comparison with healthy controls. Methodology We examined [N = 28] controls 37] group matched age, sex handedness. Using 3 Tesla – MRI, bilateral hippocampi were manually segmented blinded raters good inter-rater reliability using valid method. Additionally, Voxel-based Morphometry (VBM) analysis was performed mask. The level measured blood plasma ELISA technique. SNP genotyped PCR DNA sequencing. Psychotic symptoms assessed Scale Assessment Positive Symptoms Negative Symptoms. Results Schizophrenia had significantly deficient left right volumes after controlling potential confounding total brain volume. Plasma levels higher than significant diagnosis genotype interaction involving both volumes. Interestingly, effect only men but not women. Conclusion Our first time observations reduced Moreover, antithetical observed Together, these support "differential susceptibility" through deficit that possible neurodevelopmental origin.