FOXM1 Modulates Cisplatin Sensitivity by Regulating EXO1 in Ovarian Cancer

• DOI: 10.1371/journal.pone.0096989
• Publication Date: 2014-05-13T16:46:41Z
• Authors: Jinhua Zhou; Yunfei Wang; You Wang; Xia Yin; Yifeng He; Lilan Chen; Wenwen Wang; Ting Liu; Wen Di
• Keywords: FOXM1

Cisplatin is commonly used in ovarian cancer chemotherapy, however, chemoresistance to cisplatin remains a great clinical challenge. Oncogenic transcriptional factor FOXM1 has been reported be overexpressed cancer. In this study, we aimed investigate the potential role of cancers with cisplatin. Our results indicate that upregulated chemoresistant samples, and defends cells against cytotoxicity facilitates DNA repair through regulating direct target EXO1 protect from cisplatin-mediated apoptosis. Attenuating expression by small interfering RNA, augments chemotherapy efficacy findings targeting its gene could improve effect cancer, confirming their modulating sensitivity.