Genetic Variations Affecting Serum Carcinoembryonic Antigen Levels and Status of Regional Lymph Nodes in Patients with Sporadic Colorectal Cancer from Southern China

• DOI: 10.1371/journal.pone.0097923
• Publication Date: 2014-06-18T23:53:35Z
• Authors: Yu Liang; Weizhong Tang; Tiqiang Huang; Yong Gao; Aihua Tan; Xiaobo Yang; Haiying Zhang; Yanling Hu; Xue Qin; Shan Li; Shijun Zhang; Linjian Mo; Zhenjia Liang; Deyi Shi; Zhang Huang; Yingyong Guan; Jicheng Zhou; Cheryl Winkler; Stephen J. O'Brien; Jianfeng Xu; Zengnan Mo; Tao Peng
• Keywords: Carcinoembryonic antigen

Background Serum carcinoembryonic antigen (sCEA) level might be an indicator of disease. Indeed, elevated sCEA is a prognostic factor in colorectal cancer (CRC) patients. However, the genetic determinants healthy and CRC population remains unclear. Thus we investigated markers associated with serum these two populations its clinical implications. Methods Findings Genome-wide association study (GWAS) was conducted cohort 4,346 male adults using Illumina Omni 1 M chip. Candidate SNPs levels were validated 194 patients on ABI Taqman platform. Eight candidate The rs1047781 (chr19- FUT2) (A/T) levels, rs8176746 (chr9- ABO) regional lymph metastasis preoperative risk for tumor recurrence 5 years after operation (OR = 1.427, 95% CI: 1.005∼1.843, P 0.006). It also one factors node 2.266, 1.196∼4.293, 0.012). rs1047781-T carriers higher than that A without (P homozygote AA more common heterozygote AG 0.022). In addition, rs1047781-AT TT exhibited worse disease-free survival genotype 0.023). Conclusions We found both males population. Rs1047781 may susceptible locus from Southern China.