Genome-Wide Analysis of miRNA Signature in the APPswe/PS1ΔE9 Mouse Model of Alzheimer's Disease

• DOI: 10.1371/journal.pone.0101725
• Publication Date: 2014-08-22T19:11:29Z
• Authors: Hongxue Luo; Qi Wu; Xiaoyang Ye; Yi Xiong; Jinyong Zhu; Junyu Xu; Yarui Diao; Duo Zhang; Maosheng Wang; Jinhua Qiu; Jianting Miao; Wei Zhang; Jun Wan
• Keywords: Pathogenesis

Alzheimer's disease (AD) is the most common cause of dementia. One pathological hallmarks AD amyloid β (Aβ) deposition. MicroRNAs (miRNAs) are small non-coding RNAs whose expression levels change significantly during neuronal pathogenesis and may be used as diagnostic markers. Some miRNAs important in development by targeting genes responsible for Aβ metabolism. However, a systematic assessment miRNA profile induced Aβ-mediated still lacking. In present study, we examined using APPswe/PS1ΔE9 mouse model AD. Two sibling pairs mice were examined, showing 30 24 with altered from each paired control, respectively. Nine known both groups. Prediction putative target functional annotation implied that these affect many mainly involved PI3K/Akt signaling pathway. This study provides general regulated Aβ-associated signal pathways, which helpful to understand mechanism Aβ-induced dysfunction development.