MicroRNA-493 Suppresses Tumor Growth, Invasion and Metastasis of Lung Cancer by Regulating E2F1

• DOI: 10.1371/journal.pone.0102602
• Publication Date: 2014-08-08T18:36:15Z
• Authors: Yixue Gu; Ye Cheng; Ying Song; Zhijie Zhang; Min Deng; Chengkun Wang; Guopei Zheng; Zhimin He
• Keywords: Ectopic expression; Tumor progression

miRNAs have been proposed to be key regulators of progression and metastasis in cancer. However, an understanding their roles molecular mechanisms is needed provide deeper insights for better therapeutic opportunities. In this study we investigated the role mechanism miR-493 development nonsmall-cell lung cancer (NSCLC). Our data indicated that expression was markedly reduced pulmonary carcinoma. The ectopic impaired cell growth invasion vitro vivo. Mechanically, commonly directly targeted E2F1, which resulted a robust reduction mRNA protein. This effect, turn, decreased growth, cells. findings highlight importance dysfunction promoting tumor progression, implicate as potential target