Effects of Maternal Smoking on the Placental Expression of Genes Related to Angiogenesis and Apoptosis during the First Trimester

• DOI: 10.1371/journal.pone.0106140
• Publication Date: 2014-08-28T14:23:00Z
• Authors: Akihiro Kawashima; Keiko Koide; Walter Ventura; Kyoko Hori; Shin Takenaka; Daisuke Maruyama; Ryu Matsuoka; Kiyotake Ichizuka; Akihiko Sekizawa
• Keywords: Cotinine; HIF1A

Objective Maternal cigarette smoking is reportedly associated with miscarriage, fetal growth restriction and placental abruption, paradoxically a decreased risk of developing preeclampsia. In the present study, we investigated gene expression levels villous tissues in early gestation. We compared genes related to angiogenesis apoptosis obtained from non-smoking pregnant women. Materials Methods collected tissue samples 57 women requesting surgical termination due non-medical reasons at 6–8 weeks The maternal status was evaluated by level serum cotinine patients were divided into active smokers non-smokers level. VEGFA, PGF, FLT1, HIF1A, TP53, BAX BCL2 mRNA quantified real time PCR. Results PGF HIF1A smoker group significantly higher than that non-smoker group. did not observe any significant differences VEGFA or FLT1 between groups. group, TP53 those ratio BAX/BCL2 Conclusions Our findings revealed might affect placenta during pregnancy. pregnancy may be villus hypoxia, which influence apoptosis.