MBP-Positive and CD11c-Positive Cells Are Associated with Different Phenotypes of Korean Patients with Non-Asthmatic Chronic Rhinosinusitis

• DOI: 10.1371/journal.pone.0111352
• Publication Date: 2014-10-31T18:06:31Z
• Authors: Dong-Kyu Kim; Min-Hyun Park; Dong-Yeop Chang; Kyung Mi Eun; Hyun-Woo Shin; Ji-Hun Mo; Eui-Cheol Shin; Hong Ryul Jin; Sue Shin; Eun Youn Roh; Doo Hee Han; Dae Woo Kim
• Keywords: Nasal Polyps; Tryptase; CD163; Innate lymphoid cell; Eosinophilic Esophagitis; CD11c; CD68

Background Asthmatic nasal polyps primarily exhibit eosinophilic infiltration. However, the identities of immune cells that infiltrate non-asthmatic remain unclear. Thus, we thought to investigate distribution innate and its clinical relevance in chronic rhinosinusitis (CRS) Korea. Methods Tissues from uncinate process (UP) were obtained controls (n = 18) CRS without (CRSsNP, n 45). Nasal (NP) UP with (CRSwNP, 56). The was evaluated by immunohistochemistry such as, eosinophil major basic protein (MBP), tryptase, CD68, CD163, CD11c, 2D7, human neutrophil elastase (HNE) analyzed according parameters. Results In comparisons between each group, CRSwNP had a higher number MPB+, CD68+, CD11c+ relative CRSsNP. Comparisons NP indicated have MBP+, CD163+, CD11c+, 2D7+ HNE+ cells, whereas fewer CD68+ found NP. addition, MBP+ increased CRSsNP, CRSwNP, CRSwNP. Moreover, positively correlated CT scores. analysis phenotype, allergic tryptase+, than others, non-eosinophilic showed mainly infiltration cells. Conclusions show significant association phenotype disease extent status also may influences cellular