Altered Clock Gene Expression in Obese Visceral Adipose Tissue Is Associated with Metabolic Syndrome

• DOI: 10.1371/journal.pone.0111678
• Publication Date: 2014-11-03T19:08:16Z
• Authors: Elaine Vieira; Elena G. Ruano; Ana Lucia C. Figu...; Gloria Aranda; Dulce Momblan; Francesc Carmona; Ramon Gomis; Josep Vidal; Felicia A. Hanzu
• Keywords: PER2; PER1

Clock gene expression was associated with different components of metabolic syndrome (MS) in human adipose tissue. However, no study has been done to compare the clock genes visceral tissue (VAT) from lean and obese subjects its clinical implications. Therefore, we studied women endogenous 24 h isolated adipocytes association MS components. VAT obtained (BMI 21–25 kg/m2; n = 21) morbidly >40 28). The pattern analyzed every 6 hours using RT-PCR. Correlation data by Spearman analysis. showed that obesity alters CLOCK, BMAL1, PER1, CRY2 REV-ERB ALPHA changes found throughout period. same results were confirmed stromal cells (SC) showing an upregulation women. A positive correlation observed for BMI waist circumference population. Expression ROR correlated HDL levels CLOCK LDL. Obese exhibited PER2 LDL cholesterol, whereas circumference. We identified as upregulated during period is important MS.