Creating an African HIV Clinical Research and Prevention Trials Network: HIV Prevalence, Incidence and Transmission

• DOI: 10.1371/journal.pone.0116100
• Publication Date: 2015-01-20T18:50:04Z
• Authors: Anatoli Kamali; Matt A. Price; Shabir Lakhi; Etienne Karita; Mubiana Inambao; Eduard J. Sanders; Omu Anzala; Mary H. Latka; Linda-Gail Bekker; Pontiano Kaleebu; Gershim Asiki; Ali Ssetaala; Eugene Ruzagira; Susan Allen; Paul Farmer; Eric Hunter; Gaudensia Mutua; Heeran Makkan; Amanda Tichacek; Ilene K. Brill; Pat Fast; Gwynn Stevens; Paramesh Chetty; Pauli N. Amornkul; Jill Gilmour
• Keywords: Pre-exposure prophylaxis

HIV epidemiology informs prevention trial design and program planning. Nine clinical research centers (CRC) in sub-Saharan Africa conducted observational studies populations at risk for infection as part of an vaccine network. Annual incidence ranged from below 2% to above 10% varied by CRC group, with rates 5% observed Zambian men HIV-discordant relationship, Ugandan Lake Victoria fishing communities, who have sex men, several cohorts women. tended fall after the first three months study over calendar time. Among suspected transmission pairs, 28% infections were not reported partner. Volunteers high successfully identified enrolled into large scale cohort studies. Over a quarter new cases couples acquired persons other than transmitting