Impact of Exposure to Intimate Partner Violence on CD4+ and CD8+ T Cell Decay in HIV Infected Women: Longitudinal Study

• DOI: 10.1371/journal.pone.0122001
• Publication Date: 2015-03-29T02:28:45Z
• Authors: Rachel Jewkes; Kristin Dunkle; Nwabisa Jama-Shai; Glenda Gray
• Keywords: Longitudinal Study

Intimate partner violence (IPV) is a risk factor for HIV acquisition in many settings, but little known about its impact on cellular immunity especially infected women, and if any differs according to the form of IPV. We tested hypotheses that exposure IPV, non-partner rape, hunger, pregnancy, depression substance abuse predicted change CD4+ CD8+ T-cell count dataset 103 young women aged 15-26 enrolled cluster randomised controlled trial. Multiple regression models were fitted measure rate CD4 CD8 including terms age, person years CD4+/CD8+ observation, positivity at baseline, stratum. Exposure variables included drug use, emotional, physical or sexual IPV exposure, pregnancy food insecurity. Mean T cell baseline (or first HIV+ test) was 567.6 (range 1121-114). Participants followed an average 1.3 years. The magnitude T-cells significantly associated with having ever experienced emotional from current test (Coeff -132.9 95% CI -196.4, -69.4 p<0.0001) use -129.9 -238.7, -21.2 p=0.02). It not other measures. prior -178.4 95%CI -330.2, -26.5 In ART-naive positive gender-based faster decline markers immunity. This highlights importance attending when studying physiological experience mechanisms women's health.