Novel Clinical Evidence of an Association between Homocysteine and Insulin Resistance in Patients with Hypothyroidism or Subclinical Hypothyroidism

• DOI: 10.1371/journal.pone.0125922
• Publication Date: 2015-05-04T22:35:21Z
• Authors: Ning Yang; Zhi Yao; Li Miao; Jia Liu; Xia Gao; Hui Fan; Yanjin Hu; Heng Zhang; Yuan Xu; Aijuan Qu; Guang Wang
• Keywords: Subclinical infection; Hyperhomocysteinemia; Homeostasis; Homeostatic model assessment

Objective Hypothyroidism (HO) can induce significant metabolic dysfunction and increase cardiovascular disease risk. In the present study, we investigated relationship between homocysteine (Hcy) insulin resistance (IR) in patients with HO or subclinical hypothyroidism (SHO). Methods A total of 270 subjects were enrolled. All divided into following three groups: HO, SHO control. Plasma levels Hcy measured, each patient's homeostatic index (HOMA-IR) was calculated. Statistical analyses carried out to evaluate correlations among groups determine predictors IR SHO. Results The HOMA-IR value significantly higher group than control groups. markedly increased compared those controls. addition, plasma positively correlated values both Multiple linear regression models showed that free thyroxine (FT4) only Conclusions Our results suggest may risk for atherogenesis by IR. induced hyperhomocysteinemia partially explain this adverse effect.