Resveratrol Ameliorates Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice

• DOI: 10.1371/journal.pone.0126599
• Publication Date: 2015-05-12T17:54:09Z
• Authors: Thomas Nordstrøm ...; Kasper Thorsen; Niels Jessen; Karin Stenderup; Steen Bønløkke Pe...
• Keywords: Imiquimod

Background The polyphenol resveratrol has anti-inflammatory effects in various cells, tissues, animals and human settings of low-grade inflammation. Psoriasis is a disease both localized systemic Sirtuin1 enzyme thought to mediate the present skin known down regulate NF-κB; an important contributor development psoriasis. Consequently we investigated whether effect on Imiquimod induced psoriasis-like inflammation mice sought identify candidate genes, pathways interleukins mediating effects. Methods study consisted three treatment groups: A control group, group Imiquimod+resveratrol group. severity was assessed using elements Area Severity Index, thickness measurements, histological examination. We performed RNA microarray from lesional afterwards Ingenuity pathway analysis affected signalling pathways. Our compared previously deposited determine if gene changes were psoriasis-like, findings could be relevant setting. Results Resveratrol significantly diminished revealed expression-profile treated highlighted several dependent such as increased expression genes associated with retinoic acid stimulation reduced involved IL-17 Quantitative PCR confirmed decrease mRNA levels IL-17A IL-19; central developing Conclusions ameliorates psoriasis, stimulated pathways, IL-19 beneficial manner, which suggests resveratrol, might have role psoriasis should explored further