p53 Represses the Oncogenic Sno-MiR-28 Derived from a SnoRNA

• DOI: 10.1371/journal.pone.0129190
• Publication Date: 2015-06-10T14:13:06Z
• Authors: Feng Yu; Cameron P. Bracken; Katherine A. Pillman; David M. Lawrence; Gregory J. Goodall; David F. Callen; Paul M. Neilsen
• Keywords: Small nucleolar RNA; Crosstalk

p53 is a master tumour repressor that participates in vast regulatory networks, including feedback loops involving microRNAs (miRNAs) regulate and themselves are direct transcriptional targets. We show here group of polycistronic miRNA-like non-coding RNAs derived from small nucleolar (sno-miRNAs) transcriptionally repressed by through their host gene, SNHG1. The most abundant these, sno-miR-28, directly targets the p53-stabilizing TAF9B. Collectively, p53, SNHG1, sno-miR-28 TAF9B form loop which affects stability downstream p53-regulated pathways. In addition, SNORD28 all significantly upregulated breast tumours overexpression promotes epithelial cell proliferation. This research has broadened our knowledge crosstalk between RNA pathways roles sno-miRNAs regulation.