Non-Linear Concentration-Response Relationships between Ambient Ozone and Daily Mortality

• DOI: 10.1371/journal.pone.0129423
• Publication Date: 2015-06-15T14:21:42Z
• Authors: Sanghyuk Bae; Youn-Hee Lim; Saori Kashima; Takashi Yorifuji; Yasushi Honda; Ho Kim; Yun-Chul Hong
• Keywords: Generalized additive model; Linear relationship

Ambient ozone (O3) concentration has been reported to be significantly associated with mortality. However, linearity of the relationships and presence a threshold controversial.The aim present study was examine concentration-response relationship association between ambient O3 non-accidental mortality in 13 Japanese Korean cities from 2000 2009.We selected which have population over 1 million. We constructed Poisson regression models adjusting daily mean temperature, PM10, humidity, time trend, season, year, day week, holidays yearly population. The examined using linear, spline linear-threshold models. thresholds were estimated for each city, by constructing also city-combined generalized additive mixed model.The did not differ greatly Korea Japan, 26.2 ppb 24.2 ppb, respectively. Seven out showed better fits model compared linear model, supporting non-linear All 7 J or U shaped associations suggesting existence thresholds. range city-specific 11 34 ppb. analysis around 30-40 ppb.We observed number death cities.