Vitamin D Deficiency and Cardiometabolic Risks: A Juxtaposition of Arab Adolescents and Adults

• DOI: 10.1371/journal.pone.0131315
• Publication Date: 2015-07-17T18:10:50Z
• Authors: Nasser M. Al-Daghri; Yousef Al-Saleh; Naji Aljohani; Majed Alokail; Omar Al-Attas; Abdullah M. Alnaami; Shaun Sabico; Maha Alsulaimani; Mohammed Al-Harbi; Hanan Alfawaz; George P. Chrousos
• Keywords: Abdominal obesity

The recent exponential surge in vitamin D research reflects the global epidemic of deficiency and its potential impact on several chronic diseases both children adults. Several subpopulations, including Arab adolescent boys girls, remain understudied. This study aims to fill this gap. A total 2225 apparently healthy Saudi adolescents (1187 1038 aged 13-17 years old) 830 adults (368 men 462 women, 18-50 were respectively recruited from different public schools medical practices within Riyadh, Arabia. Anthropometrics taken fasting blood samples withdrawn examine serum glucose lipid profile by routine analysis 25-hydroxyvitamin ELISA. Almost half girls (47.0%) had as compared only 19.4% (p<0.001), 36.8% adult women 17.7% (p<0.001). Furthermore, there more significant inverse associations between 25(OH)vitamin levels cardiometabolic indices than while contrast men. Vitamin was significantly associated with diabetes mellitus type 2 (DMT2) [OR 3.47 (CI1.26-5.55); p<0.05] pre-DM 2.47 (CI 1.48-4.12); p<0.01] boys. insufficiency abdominal obesity 2.75 1.1-7.1); p<0.05]. These for DMT2 not observed males, women. deficiency/insufficiency hyperglycemia is high among adolescents. mostly risk factors indicates a sex- age-related disadvantage low status challenges extra-skeletal protection correction females.