Conization Using an Electrosurgical Knife for Cervical Intraepithelial Neoplasia and Microinvasive Carcinoma

• DOI: 10.1371/journal.pone.0131790
• Publication Date: 2015-07-08T17:53:42Z
• Authors: Libing Xiang; Jiajia Li; Wentao Yang; Xiaoli Xu; Xiaohua Wu; Huaying Wang; Ziting Li; Huijuan Yang
• Keywords: Cervical conization; Carcinoma in situ

Objective The aim of the present study was to evaluate incidences margin involvement, disease relapse, and complications in patients who had undergone conization using an electrosurgical knife (EKC) for cervical intraepithelial neoplasia (CIN) or microinvasive carcinomas (micro-CAs). Materials Methods A retrospective case series analysis performed with a total 1359 underwent EKC Fudan University Shanghai Cancer Center between June 2004 July 2010. Results median age 39 years old (range: 19-72). Conization revealed presence CIN 1113 (81.9%) patients, micro-CA 72 (5.3%) invasive 44 (3.2%) patients. remaining 130 (9.6%) were free diseases cone specimens. Positive surgical margins, endocervical curettages (ECCs) found 90 (7.6%) CINs micro-CAs. Three factors associated positive margins ECCs included (>50 years; odds ratio (OR), 3.0, P<0.01), postmenopausal status (OR, 3.1, P<0.01) 2.7, P<0.01). One thousand eighty-nine (92.0%) followed-up regularly follow-up duration 46 months 24-106 months). Disease relapse documented 50 (4.6%) Eighty-two (6.0%) cases experienced that needed be addressed, including early late hemorrhages, infections, stenosis, etc. Conclusions Our demonstrated alternative technique diagnosis treatment micro-CAs relatively low rate recurrence acceptable complications. randomized clinical trial is warranted compare EKC, CKC LEEP management micro-CA.