Vγ9Vδ2 T-Cell Polyfunctionality Is Differently Modulated in HAART-Treated HIV Patients according to CD4 T-Cell Count

• DOI: 10.1371/journal.pone.0132291
• Publication Date: 2015-07-10T18:26:33Z
• Authors: Rita Casetti; Gabriele De Simone; Alessandra Sacchi; Alessandra Rinaldi; Domenico Viola; Chiara Agrati; Veronica Bordoni; Eleonora Cimini; Nicola Tumino; Francesca Besi; Federico Martini
• Keywords: Cd4 t cell

Alteration of γδ T-cell distribution and function in peripheral blood is among the earliest defects during HIV-infection. We asked whether polyfunctional response could also be affected, how this impairment associated to CD4 count. To aim, we performed a cross-sectional study on HIV-infected individuals. In order evaluate polyfunctional-Vγ9Vδ2 after phosphoantigen-stimulation, assessed cytokine/chemokine production cytotoxicity by flow-cytometry HAART-treated-HIV+ persons healthy-donors. During HIV-infection Vγ9Vδ2-polyfunctional quality since several Vγ9Vδ2 subsets resulted significantly lower HIV+ patients respect healthy donors. Interestingly, found weak positive correlation between T-cell-response counts. By dividing according count, that Low-CD4 expressed number two expressing MIP-1β different combinations with other molecules (CD107a/IFNγ) High-CD4 Our results show specifically suggesting direct link innate T-cells These findings suggest may indirectly influenced HAART therapy included new therapeutical strategy which would perform an important role fighting HIV infection.