Obstruction of Venous Drainage Linked to Transient Global Amnesia

• DOI: 10.1371/journal.pone.0132893
• Publication Date: 2015-07-14T18:14:00Z
• Authors: Ke Han; A-Ching Chao; Feng-Chi Chang; Chih-Ping Chung; Hung-Yi Hsu; Wen-Yung Sheng; Jiang Wu; Han-Hwa Hu
• Keywords: Transient global amnesia; Valsalva maneuver; Internal jugular vein; Magnetic resonance angiography; Venous pressure

Abnormal extracranial venous drainage modality has been considered an etiology of transient global amnesia (TGA). Evidence suggests that the transmission intrathoracic/intraabdominal pressure during a Valsalva maneuver (VM) is mainly through vertebral system, and patency internal jugular vein (IJV) essential for releasing. We hypothesize obstruction IJV contributing factor in TGA pathogenesis. A magnetic resonance (MR) imaging protocol was used 45 patients age- sex-matched controls to assess morphologies IJV, brachiocephalic (BCV) asymmetry transverse sinus (TS). The divided into upper- middle-IJV segments. Compared controls, had significantly higher rates moderate severe compression/stenosis at bilateral upper-IJV segment (left: 37.8% vs. 17.8%, P = 0.0393; right: 57.8% vs.15.6%, P<0.0012), left BCV (60% 8.9%, P<0.0004), TS hypoplasia (53.3%% 31.1%, 0.0405). prevalence least one site or than (91.1% 33.3%, P<0.0004). diameter MRV, but not T1 contrast imaging, smaller (0.31±0.21 0.41±0.19, 0.0290), which compatible with downstream stenosis/obstruction. have hypoplasia, new evidence supports role veins