Association of VDR and CYP2R1 Polymorphisms with Mite-Sensitized Persistent Allergic Rhinitis in a Chinese Population

• DOI: 10.1371/journal.pone.0133162
• Publication Date: 2015-07-15T14:41:30Z
• Authors: Hui-Qin Tian; Xin-Yuan Chen; Ying Lu; Wen-Min Lu; Mei-Lin Wang; Hai-Long Zhao; Mei-Ping Lu; Han Zhou; Ruo-Xi Chen; Zheng-Dong Zhang; Chong Shen; Lei Cheng
• Keywords: Adult; Male; China; Adolescent; Science; 03 medical and health sciences; 0302 clinical medicine; Asian People; Gene Frequency; Animals; Humans; Genetic Predisposition to Disease; Child; Cytochrome P450 Family 2; Genetic Association Studies; Aged; Q; R; Epistasis, Genetic; Middle Aged; 3. Good health; Genetic Loci; Case-Control Studies; Child, Preschool; Medicine; Cholestanetriol 26-Monooxygenase; Female; Research Article

As recent studies have described an association between vitamin D and allergic rhinitis, we hypothesized that pathway-related genes may be candidate for susceptibility to rhinitis. Thus, sought evaluate whether polymorphisms in the receptor (VDR) CYP2R1 are associated with mite-sensitized persistent rhinitis (PER) a Han Chinese population. A hospital-based case-control study consisting of 519 patients PER 447 healthy controls was conducted. Five single nucleotide (SNPs) VDR were selected genotyping. The genotype allele frequencies rs9729, rs2228570, rs1544410, rs731236 as well rs2060793 not significantly PER. After stratification analyses, however, both CT CT/TT genotypes rs2228570 exhibited decreased risk (CT: adjusted odds ratio (OR)=0.58, 95% confidence intervals (CI)=0.37-0.91; CT/TT: OR=0.61, CI=0.40-0.93) PER, while AA increased (adjusted OR=1.85, CI=1.03-3.34) age subgroup <16 years old. Both AG AG/GG (AG: OR=0.43, CI=0.21-0.89; AG/GG: OR=0.46, CI=0.23-0.94) female subgroup. Analysis locus-locus interactions revealed two models involved combined SNPs statistically significant (P<0.05). Our data suggest gender impact on three (rs2228570, rs731236, rs2060793) pathway this variants genetic pathogenesis