Pre-Altitude Serum Ferritin Levels and Daily Oral Iron Supplement Dose Mediate Iron Parameter and Hemoglobin Mass Responses to Altitude Exposure

• DOI: 10.1371/journal.pone.0135120
• Publication Date: 2015-08-11T17:52:02Z
• Authors: Andrew D. Govus; Laura A. Garvican...; Chris R. Abbiss; Peter Peeling; Christopher J. Gore
• Keywords: Transferrin saturation; Altitude training; Soluble transferrin receptor

To investigate the influence of daily oral iron supplementation on changes in hemoglobin mass (Hbmass) and parameters after 2-4 weeks moderate altitude exposure.Hematological data collected from 178 athletes (98 males, 80 females) exposed to (1,350-3,000 m) were analysed using linear regression determine how exposure combined with influenced Hbmass, total incorporation (TII) blood [ferritin transferrin saturation (TSAT)].Altitude (mean ± s: 21 3 days) increased Hbmass by 1.1% [-0.4, 2.6], 3.3% [1.7, 4.8], 4.0% [2.0, 6.1] pre-altitude levels who ingested nil, 105 mg 210 respectively, supplement daily. Serum ferritin decreased -33.2% [-46.9, -15.9] 13.8% [-32.2, 9.7] supplemented nil daily, but 36.8% [1.3, 84.8] Finally, either or had a greater TII compared non-supplemented (0 versus mg: effect size (d) = -1.88 [-2.56, -1.17]; 0 -2.87 [-3.88, -1.66]).Oral during may enhance production assist maintenance balance some low stores.