Cytoprotective Effects of Lysophospholipids from Sea Cucumber Holothuria atra

• DOI: 10.1371/journal.pone.0135701
• Publication Date: 2015-08-14T18:18:51Z
• Authors: Yoshifumi Nishikawa; Ayumi Furukawa; Ikumi Shiga; Yoshikage Muroi; Toshiaki Ishii; Yayoi Hongo; Shunya Takahashi; Tatsuya Sugawara; Hiroyuki Koshino; Masao Ohnishi
• Keywords: Lysophosphatidylcholine; Platelet-activating factor

Lysophospholipids are important signaling molecules in animals and metazoan cells. They widely distributed among marine invertebrates, where their physiological roles unknown. Sea cucumbers produce unique lysophospholipids. In this study, two lysophospholipids were detected Holothuria atra for the first time, lyso-platelet activating factor lysophosphatidylcholine, with nuclear magnetic resonance liquid chromatography–time-of-flight mass spectrometric analyses. The lipid fraction of H. contained inhibited H2O2-induced apoptosis macrophage cell line J774A.1. antioxidant activity lysophospholipid-containing was confirmed oxygen radical absorbance capacity method. Our results suggest that from potential therapeutic agents inflammation induced by oxidative stress.