Differences in Retinal Structure and Function between Aging Male and Female Sprague-Dawley Rats are Strongly Influenced by the Estrus Cycle

• DOI: 10.1371/journal.pone.0136056
• Publication Date: 2015-08-28T14:17:31Z
• Authors: Samaneh Chaychi; Anna Polosa; Pierre Lachapelle
• Keywords: Electroretinography; Erg; Histology; Sexual dimorphism

Purpose Biological sex and age are considered as two important factors that may influence the function structure of retina, an effect might be governed by sexual hormones such estrogen. The purpose this study was to delineate biological exert on retinal rodents also clarify estrus cycle female rats. Method 50 normal male albino Sprague-Dawley (SD) rats investigated with electroretinogram (ERG) at postnatal day (P) 30, 60, 100, 200, 300 (n = 5–6 rats/age). Following ERG recording sessions, histology performed in both sexes. In parallel, premenopausal menopausal aged P540 were compared. Results Sex age-related changes observed our animal model. However, irrespective age, no significant difference obtained from Notwithstanding above we did however notice between P60 P200 there a gradual increase amplitudes compared males. Furthermore, 18 months old (P540) larger age-matched well Conclusion Our results showed can SD cycled have better suggesting beneficial function.