23Na Magnetic Resonance Imaging of the Lower Leg of Acute Heart Failure Patients during Diuretic Treatment

• DOI: 10.1371/journal.pone.0141336
• Publication Date: 2015-10-26T17:41:16Z
• Authors: Matthias Hammon; Susan Grossmann; Peter Linz; Christoph Kopp; Anke Dahlmann; Christoph Garlichs; Rolf Janka; Alexander Cavallaro; Friedrich C. Luft; Michael Uder; Jens Titze
• Keywords: Male; Science; -; 03 medical and health sciences; 0302 clinical medicine; Medizinische Fakultät; Humans; ddc:610; Prospective Studies; Diuretics; Muscle, Skeletal; Aged; Skin; Aged, 80 and over; Heart Failure; Leg; Q; Sodium; R; Water; Middle Aged; Magnetic Resonance Imaging; 3. Good health; Cardiovascular and Metabolic Diseases; Case-Control Studies; Medicine; Female; Research Article

Objective Na+ can be stored in muscle and skin without commensurate water accumulation. The aim of this study was to assess H2O with MRI acute heart failure patients before after diuretic treatment a healthy cohort. Methods Nine (mean age 78 years; range 58–87) nine gender-matched controls were studied. They underwent 23Na/1H-MRI at the calf custom-made knee coil. Patients studied therapy. 23Na-MRI gray-scale measurements Na+-phantoms served quantify Na+-concentrations. A fat-suppressed inversion recovery sequence used content. Results Plasma Na+-levels did not change during Mean Na+-concentrations decreased furosemide therapy (before therapy: 30.7±6.4 43.5±14.5 mmol/L; 24.2±6.1 32.2±12.0 p˂0.05 p˂0.01). Water content differ significantly (p = 0.17) only tended reduced 0.06). higher than subjects (18.3±2.5 21.1±2.3 mmol/L). Conclusions shows accumulation failure. Diuretic mobilize Na+-deposition; however, contrary expectations, Na+-mobilization are poorly correlated.