Skin Commensal Staphylococci May Act as Reservoir for Fusidic Acid Resistance Genes

• DOI: 10.1371/journal.pone.0143106
• Publication Date: 2015-11-18T18:59:06Z
• Authors: Wei-Chun Hung; Hsiao-Jan Chen; Yu-Tzu Lin; Jui-Chang Tsai; Chiao-Wei Chen; Hsiao-Hung Lu; Sung-Pin Tseng; Yao-Yu Jheng; Kin Hong Leong; Lee-Jene Teng
• Keywords: Fusidic acid; Staphylococcus haemolyticus; SCCmec

We analyzed the occurrence and mechanisms of fusidic acid resistance present in staphylococci isolated from 59 healthy volunteers. The fingers volunteers were screened for presence staphylococci, collected isolates tested to acid. A total 34 resistant staphylococcal strains (all coagulase-negative) 22 individuals (22/59, 37.3%). Examination genes revealed that acquired fusB or fusC was Staphylococcus epidermidis, capitis subsp. urealyticus, hominis hominis, warneri haemolyticus. Resistance islands (RIs) carrying found S. epidermidis while chromosome cassette (SCC)-related structures harboring hominis. Genotypic analysis indicated fus elements disseminated diverse genetic strain backgrounds. highly homologous SCCfusC epidemic sequence type (ST) 239/SCCmecIII methicillin-resistant aureus (MRSA) pseudo SCCmec ST779 MRSA. their environment commensal suggested skin may act as reservoir genes.